Article
Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Sept 2023
Kozlova Alena A, Rubets Elena, Vareltzoglou Magdalini R, Jarzebska Natalia, Ragavan Vinitha N, Chen Yingjie, Martens-Lobenhoffer Jens, Bode-Böger Stefanie M, Gainetdinov Raul R, Rodionov Roman N, Bernhardt Nadine
Abstract excerpt
The enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) plays a pivotal role in the regulation of nitric oxide levels by degrading the main endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). Growing evidence highlight the potential implication of DDAH/ADMA axis in the etiopathogenesis of several neuropsychiatric and neurological disorders, yet the underlying molecular mechanisms...
Topics
- Animals
- Female
- Mice
- Amidohydrolases
- Amphetamine
- Dopamine
- Enzyme Inhibitors
- Genotype
- Mice, Knockout
- Nitric Oxide