Article
Aberrantly Activated APOBEC3B Is Associated With Mutant p53-Driven Refractory/Relapsed Diffuse Large B-Cell Lymphoma.
Frontiers in immunology - 1 Jan 2022
Zhang Xuzhao, Wu Zhaoxing, Hao Yuanyuan, Yu Teng, Li Xian, Liang Yun, Li Jinfan, Huang Liansheng, Xu Yang, Li Xiuzhen, Xu Xiaohua, Wang Weiqin, Xu Genbo, Zhang Xiaohong, Lv Qinghua, Fang Yongming, Xu Rongzhen, Qian Wenbin
Abstract excerpt
Tumor protein 53 (TP53) mutation predicts an unfavorable prognosis in diffuse large B-cell lymphoma (DLBCL), but the molecular basis for this association remains unclear. In several malignancies, the cytidine deaminase apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B) has been reported to be associated with the TP53 G/C-to-A/T mutation. Here, we show that the frequency of this mutation was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.