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Article

Clinical aspects of TP53 gene inactivation in diffuse large B-cell lymphoma

1 Mar 2019

Abstract excerpt

BACKGROUND: The knowledge about specific mechanisms generating TP53 dysfunction in diffuse large B-cell lymphoma is limited. The aim of the current study was to comprehensively explore TP53 gene variability resulting from somatic mutations, promoter methylation, and allelic imbalance in tumorous tissue of diffuse large B-cell lymphoma (DLBCL). METHODS: DNA samples from 74 patients with DLBCL were used. Genomic...

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PMID: 30871527
DOI: 10.1186/s12920-019-0484-9

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