Article
APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers.
Breast cancer (Tokyo, Japan) - 1 Sept 2016
Tsuboi Miki, Yamane Arito, Horiguchi Jun, Yokobori Takehiko, Kawabata-Iwakawa Reika, Yoshiyama Shinji, Rokudai Susumu, Odawara Hiroki, Tokiniwa Hideaki, Oyama Tetsunari, Takeyoshi Izumi, Nishiyama Masahiko
Abstract excerpt
BACKGROUND: The members of AID/APOBEC protein family possess cytidine deaminase activity that converts cytidine residue to uridine on DNA and RNA. Recent studies have shown the possible influence of APOBEC3B (A3B) as DNA mutators of breast cancer genome. However, the clinical significance of A3B expression in Japanese breast cancer has not been studied in detail. METHODS: Ninety-three primary breast cancer...
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