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Article

TP53 mutation predict poor prognosis in diffuse large B-cell lymphoma: a single-center study.

Annals of hematology - 29 Jan 2026

Zhang Haiyan, Zhang Xiang, Wang Jinghan, Zhang Xuewu, Lv Yunfei, Zhu Yanan, Ye Xingnong, Wei Juying, Yang Min, Xu Gaixiang, Yang Chunmei, Meng Haitao, Xie Wanzhuo, Jin Jie, Tong Hongyan, Yu Wenjuan

Abstract excerpt

Whether TP53 mutation can serve as a simplified prognostic surrogate for complex genomic classifiers in diffuse large B-cell lymphoma (DLBCL) remains unclear. we comprehensively analyzed a retrospective cohort of 444 newly diagnosed DLBCL patients. TP53 mutation was an independent prognostic factor for inferior overall survival (OS) and progression-free survival (PFS) (both P < 0.001), correlating with inferior...

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Identifiers

PMID: 41609884
DOI: 10.1007/s00277-026-06821-8
PMCID: PMC12855322

Genes

TP53

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TP53 mutation predict poor prognosis in diffuse large B-cell lymphoma: a single-center study.PMID 41609884Read ↗

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