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Article

Higher frequency of p53 gene mutations in diffuse large B-cell lymphoma with MALT component.

Pathology international - 1 Nov 2004

Tai Yan-Chin, Tan Jin-Ai Mary Anne, Peh Suat-Cheng

Abstract excerpt

p53 gene mutation is not a frequent event in the tumorigenesis of lymphomas and the expression of p53 protein is independent of p53 gene mutations. The present study aimed to investigate mutations in the p53 gene in a series of extranodal B-cell lymphomas, and its association with p53 protein expression. A total of 52 cases were graded histologically into Grade 1, Grade 2 and Grade 3 tumors and p53 protein...

Topics

Adolescent
Adult
Aged
Child
DNA Mutational Analysis
Female
Genes, p53
Humans
Immunohistochemistry
Lymphoma, B-Cell, Marginal Zone
Lymphoma, Large B-Cell, Diffuse
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 15533223
DOI: 10.1111/j.1440-1827.2004.01765.x

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