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Article

Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy

16 Jan 2017

Abstract excerpt

Androgen receptor (AR) signaling remains the major oncogenic pathway in prostate cancer (PCa). Androgen-deprivation therapy (ADT) is the principle treatment for locally advanced and metastatic disease. However, a significant number of patients acquire treatment resistance leading to castration resistant prostate cancer (CRPC). Epigenetics, the study of heritable and reversible changes in gene expression without...

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PMID: 28275218
DOI: 10.3390/cancers9010009

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