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Plasma Adrenomedullin, Allelic Variations in the ADM Gene, and Risk for Lower-Limb Amputation in People With Type 2 Diabetes.

Diabetes care - 7 Jul 2022

Potier Louis, Mohammedi Kamel, Saulnier Pierre-Jean, Fumeron Frédéric, Halimi Jean-Michel, Venteclef Nicolas, Marre Michel, Hadjadj Samy, Roussel Ronan, Velho Gilberto

Abstract excerpt

OBJECTIVE: Patients with diabetes have an increased risk for lower-limb amputation (LLA), but biomarkers to assess risk of LLA are lacking. Adrenomedullin (ADM) is a vasodilator peptide that also plays a role in fluid and electrolyte homeostasis in the kidney, increasing natriuresis and diuresis. ADM was shown to be associated with cardiovascular and renal events in diabetes, but it was not investigated in terms...

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PMID: 35583678
DOI: 10.2337/dc21-2638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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