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Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes.

Diabetes care - 1 Feb 2022

Mohammedi Kamel, Abouleka Yawa, Carpentier Charlyne, Potier Louis, Dubois Severine, Foussard Ninon, Rigalleau Vincent, Gautier Jean-François, Gourdy Pierre, Charpentier Guillaume, Roussel Ronan, Scheen André, Bauduceau Bernard, Hadjadj Samy, Alhenc-Gelas François, Marre Michel, Velho Gilberto

Abstract excerpt

OBJECTIVE: The ACE insertion/deletion (I/D) polymorphism has been widely studied in people with diabetes, albeit not with regard to lower-limb amputation (LLA). We examined associations among this polymorphism, plasma ACE concentration, and LLA in people with type 1 diabetes. RESEARCH DESIGN AND METHODS: ACE I/D genotype and plasma ACE were assessed in three prospective cohorts of participants with type 1...

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Share to Diabetes and associated disorders
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics and Physical Performance

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Share to Lower Extremity

Share to Pancreatic function and diabetes

Share to Peptidyl-Dipeptidase A

Share to Polymorphism, Genetic

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Identifiers

PMID: 34853028
DOI: 10.2337/dc21-0973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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