Article
Diabetes, lower extremity amputation, loss of protective sensation, and neuronal nitric oxide synthase associated protein in the chronic renal insufficiency cohort study.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society - 1 Jan 2000
Margolis David J, Gupta Jayanta, Thom Stephen R, Townsend Raymond R, Kanetsky Peter A, Hoffstad Ole, Papdopoulos Maryte, Fischer Michael, Schelling Jeffrey R, Mitra Nandita
Abstract excerpt
Lower extremity amputation (LEA) is a life-altering complication of diabetes. The goal of our study was to investigate the possibility that genetic variation in neuronal nitric oxide synthase associated protein (NOS1AP) is associated with LEA and diabetic peripheral neuropathy (DPN). Our work used data from the Chronic Renal Insufficiency Cohort (CRIC) study. CRIC is a multicenter investigation undertaken to...
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