Article
Adrenomedullin and arterial stiffness: integrative approach combining monocyte ADM expression, plasma MR-Pro-ADM, and genome-wide association study.
Circulation. Cardiovascular genetics - 1 Oct 2014
Beygui Farzin, Wild Philipp S, Zeller Tanja, Germain Marine, Castagné Raphaele, Lackner Karl J, Münzel Thomas, Montalescot Gilles, Mitchell Gary F, Verwoert Germaine C, Tarasov Kirill V, Trégouët David-Alexandre, Cambien François, Blankenberg Stefan, Tiret Laurence
Abstract excerpt
BACKGROUND: Adrenomedullin (ADM) is a circulating vasoactive peptide involved in vascular homeostasis and endothelial function. Single nucleotide polymorphisms of the ADM gene are associated with blood pressure variability, and elevated levels of plasma midregional proadrenomedullin (MR-pro-ADM) are associated with cardiovascular diseases. METHODS AND RESULTS: We investigated the sources of variability of ADM...
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