Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Colony‑stimulating factor CSF2 mediates the phenotypic plasticity of small‑cell lung cancer by regulating the p‑STAT3/MYC pathway

17 May 2022

Abstract excerpt

Relapse and drug resistance are the main causes of mortality in patients with small‑cell lung cancer (SCLC). Intratumoral heterogeneity (ITH) is a key biological mechanism that leads to relapse and drug resistance. Phenotypic plasticity is an important factor that leads to ITH in SCLC, although its mechanisms and key regulatory factors remain to be elucidated. In the present study, cell proliferation and cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Lung Cancer Research Studies
Share to Neuroendocrine Tumor Research Advances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35583004
DOI: 10.3892/or.2022.8333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Colony‑stimulating factor CSF2 mediates the phenotypic plasticity of small‑cell lung cancer by regulating the p‑STAT3/MYC pathwayPMID 35583004Read ↗

A comparative study of neuroendocrine heterogeneity in SCLC and NBLSemantic proximity Read ↗

Cell plasticity in patients with NSCLC: The controversial origins of transformed SCLC.Semantic proximity Read ↗

A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and NeuroblastomaSemantic proximity Read ↗

Small cell lung cancer transformation: From pathogenesis to treatment.Semantic proximity Read ↗

Dynamic phenotypic reprogramming and chemoresistance induced by lung fibroblasts in small cell lung cancer.Semantic proximity Read ↗

EGFR-mutant transformed small cell lung cancer harbors intratumoral heterogeneity targetable with MEK inhibitor combination therapy.Semantic proximity Read ↗

Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypesSemantic proximity Read ↗

PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer.Semantic proximity Read ↗

The small cell lung cancer neuroendocrine transdifferentiation explorerSemantic proximity Read ↗

Establishment and characterization of BMC-PDC-019: a novel patient-derived cell line of EGFR-mutant pulmonary adenocarcinoma transformed into small-cell lung cancer.Semantic proximity Read ↗

Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers.Semantic proximity Read ↗

Involvement of epithelial-mesenchymal transition genes in small cell lung cancer phenotypic plasticitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.