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Article

PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer.

Journal of genetics and genomics = Yi chuan xue bao - 20 Jul 2021

Li Xuefeng, Li Cheng, Guo Chenchen, Zhao Qiqi, Cao Jiayu, Huang Hsin-Yi, Yue Meiting, Xue Yun, Jin Yujuan, Hu Liang, Ji Hongbin

Abstract excerpt

Small cell lung cancer (SCLC) is a phenotypically heterogeneous disease with an extremely poor prognosis, which is mainly attributed to the rapid development of resistance to chemotherapy. However, the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear. Through comprehensive bioinformatic analyses, we found that the heterogeneity of SCLC phenotype was significantly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

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Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 34167917
DOI: 10.1016/j.jgg.2021.04.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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