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Article

Cell plasticity in patients with NSCLC: The controversial origins of transformed SCLC.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 May 2022

Liang Xinlin, Lin Anqi, Wang Qiongyao, Zhang Jian, Luo Peng

Abstract excerpt

In recent years, the application of targeted therapy has greatly improved the survival of NSCLC patients with known tumor mutations. However, the plasticity of tumor cells can drive them to transform into a phenotypic state that is no longer targeted by drugs. One of the mechanisms by which drug resistance occurs is the transformation from NSCLC to SCLC. This seems to occur because of the selection pressure...

Topics

Carcinoma, Non-Small-Cell Lung
Cell Plasticity
Humans
Lung Neoplasms
Mutation
Small Cell Lung Carcinoma

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36068773
DOI: 10.1016/j.biopha.2022.112909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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