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Article

Cell plasticity in patients with NSCLC: The controversial origins of transformed SCLC.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 May 2022

Liang Xinlin, Lin Anqi, Wang Qiongyao, Zhang Jian, Luo Peng

Abstract excerpt

In recent years, the application of targeted therapy has greatly improved the survival of NSCLC patients with known tumor mutations. However, the plasticity of tumor cells can drive them to transform into a phenotypic state that is no longer targeted by drugs. One of the mechanisms by which drug resistance occurs is the transformation from NSCLC to SCLC. This seems to occur because of the selection pressure...

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Identifiers

PMID: 36068773
DOI: 10.1016/j.biopha.2022.112909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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