Article
Comparison of In-Frame Deletion, Homology-Directed Repair, and Prime Editing-Based Correction of Duchenne Muscular Dystrophy Mutations.
Biomolecules - 22 May 2023
Zhao Xiaoying, Qu Kunli, Curci Benedetta, Yang Huanming, Bolund Lars, Lin Lin, Luo Yonglun
Abstract excerpt
Recent progress in CRISPR gene editing tools has substantially increased the opportunities for curing devastating genetic diseases. Here we compare in-frame deletion by CRISPR-based non-homologous blunt end joining (NHBEJ), homology-directed repair (HDR), and prime editing (PE, PE2, and PE3)-based correction of two Duchenne Muscular Dystrophy (DMD) loss-of-function mutations (c.5533G>T and c.7893delC). To enable...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.