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Article

Progress in the application of CRISPR: From gene to base editing.

Medicinal research reviews - 1 Mar 2019

Wu Wenyi, Yang Yanhui, Lei Hetian

Abstract excerpt

The system of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated endonucleases (Cas) has been utilized for genome editing with great accuracy and high efficiency in generating gene knockout, knockin, and point mutations in eukaryotic genomes. However, traditional CRISPR/Cas9 technology introduces double-stranded DNA breaks (DSBs) at a target locus as the first step to make...

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PMID: 30171624
DOI: 10.1002/med.21537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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