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Article

IVS I-5 (G > C) is associated with changes to the RBC membrane lipidome in response to hydroxyurea treatment in β-thalassemia patients.

Molecular omics - 11 Jul 2022

Khan Muhammad Behroz Naeem, Iftikhar Fizza, Khan Tajwali, Danish Asma, Shamsi Tahir, Musharraf Syed Ghulam, Siddiqui Amna Jabbar

Abstract excerpt

The red blood cell membrane loses its integrity during hemoglobinopathies like β-thalassemia and sickle cell disease. Various mutations have been associated with β-thalassemia, the most prevalent of which is the IVS-1-5 (G > C) mutation. It is associated with poor prognosis of the disease with a dependency on transfusion. Here, we have investigated the effect of IVS mutation and the administration of hydroxyurea...

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Identifiers

PMID: 35578989
DOI: 10.1039/d2mo00008c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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