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Article

Multiomics analysis of red blood cells reveals thalassemia severity beyond globin gene mutations.

Blood advances - 26 May 2026

Mitra Nibedita, Bhattacharyya Upasana, Chowdhury Prosanto, Pal Arijit, M Korwar Arvind, Bhattacharjee Samsidhhi, Basu Anupam

Abstract excerpt

ABSTRACT: Hemoglobinopathies are the most common monogenic genetic disorders, primarily managed through blood transfusions or bone marrow transplantation. Clinical severity other than mutational effect is not well investigated and still unknown. This study aimed to identify dysregulated molecular pathways in red blood cells (RBCs) contributing to thalassemia severity. From a cohort of 285 patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41616282
DOI: 10.1182/bloodadvances.2025016677
PMCID: PMC13207458

Genes

CDK11A
COPS7A
H3C1
HNRNPUL1
HTATSF1
MCTS1
WNK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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