Article

Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients, as a function of therapeutic transfusion and hydroxyurea treatment

2023-04-06

Abstract excerpt

Metabolomics studies in sickle cell disease (SCD) have been so far limited to tens of samples, owing to technical and experimental limitations. To overcome these limitations, we performed plasma metabolomics analyses on 596 samples from patients with sickle cell sickle cell disease (SCD) enrolled in the WALK-PHaSST study. Clinical covariates informed the biological interpretation of metabolomics data, including ge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cc9e17a-90a1-56be-a54b-c826bf74eeb4
DOI: 10.1101/2023.04.05.535693

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients, as a function of therapeutic transfusion and hydroxyurea treatmentDOI 10.1101/2023.04.05.535693Read

<i>In vivo</i> evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunctionSemantic proximity Read

Pathophysiology of sickle cell disease is mirrored by the red blood cell metabolomeSemantic proximity Read

Arginine metabolism is a biomarker of red blood cell and human agingSemantic proximity Read

Alterations of Plasma Metabolites Associated with Sickle Cell Trait.Semantic proximity Read

Metabolic and Proteomic Divergence is Present in Spleens and Livers from Berkeley Sickle Cell Anemia and β-Thalassemia MiceSemantic proximity Read

Clinical biomarkers in sickle cell diseaseSemantic proximity Read

Red blood cell metabolism in Down syndrome: hints on metabolic derangements in agingSemantic proximity Read

Plasma proteome signatures in sickle cell anaemia and effect of hydroxyurea treatmentSemantic proximity Read

Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches.Semantic proximity Read

Biomarkers of clinical severity in treated and untreated sickle cell disease: a comparison by genotypes of a single center cohort and African Americans in the NHANES study.Semantic proximity Read

Genetic variation of human G6PD impacts Red Blood Cell transfusion efficacySemantic proximity Read

Therapeutics for sickle cell disease intravascular hemolysisSemantic proximity Read