Article
Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology - 1 Jun 2018
Ikezu Tsuneya, Chen Cidi, DeLeo Annina M, Zeldich Ella, Fallin M Daniele, Kanaan Nicholas M, Lunetta Kathryn L, Abraham Carmela R, Logue Mark W, Farrer Lindsay A
Abstract excerpt
We studied the effect of two rare mutations (rs144662445 and rs149979685) in the A-kinase anchoring protein 9 (AKAP9) gene, previously associated with Alzheimer disease (AD) in African Americans (AA), on post-translational modifications of AD-related pathogenic molecules, amyloid precursor protein (APP) and microtubule-associated protein Tau using lymphoblastoid cell lines (LCLs) from 11 AA subjects with at least...
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