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Article

NUT Is a Driver of p300-Mediated Histone Hyperacetylation: From Spermatogenesis to Cancer

29 Apr 2022

Abstract excerpt

In maturing sperm cells, a major genome re-organization takes place, which includes a global increase in the acetylation of histones prior to their replacement by protamines, the latter being responsible for the tight packaging of the male genome. Understanding the function of the oncogenic BRD4-NUT fusion protein in NUT carcinoma (NC) cells has proven to be essential in uncovering the mechanisms underlying...

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PMID: 35565363
DOI: 10.3390/cancers14092234

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