Article
Lung Extracellular Matrix Hydrogels Enhance Preservation of Type II Phenotype in Primary Alveolar Epithelial Cells.
International journal of molecular sciences - 28 Apr 2022
Marhuenda Esther, Villarino Alvaro, Narciso Maria Leonor, Camprubí-Rimblas Marta, Farré Ramon, Gavara Núria, Artigas Antonio, Almendros Isaac, Otero Jorge
Abstract excerpt
One of the main limitations of in vitro studies on lung diseases is the difficulty of maintaining the type II phenotype of alveolar epithelial cells in culture. This fact has previously been related to the translocation of the mechanosensing Yes-associated protein (YAP) to the nuclei and Rho signaling pathway. In this work, we aimed to culture and subculture primary alveolar type II cells on extracellular matrix...
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