Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation.

doi:10.1038/s41586-021-04266-9

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Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation.

Nature - 1 Feb 2022

Saito Akatsuki, Irie Takashi, Suzuki Rigel, Maemura Tadashi, Nasser Hesham, Uriu Keiya, Kosugi Yusuke, Shirakawa Kotaro, Sadamasu Kenji, Kimura Izumi, Ito Jumpei, Wu Jiaqi, Iwatsuki-Horimoto Kiyoko, Ito Mutsumi, Yamayoshi Seiya, Loeber Samantha, Tsuda Masumi, Wang Lei, Ozono Seiya, Butlertanaka Erika P, Tanaka Yuri L, Shimizu Ryo, Shimizu Kenta, Yoshimatsu Kumiko, Kawabata Ryoko, Sakaguchi Takemasa, Tokunaga Kenzo, Yoshida Isao, Asakura Hiroyuki, Nagashima Mami, Kazuma Yasuhiro, Nomura Ryosuke, Horisawa Yoshihito, Yoshimura Kazuhisa, Takaori-Kondo Akifumi, Imai Masaki, Tanaka Shinya, Nakagawa So, Ikeda Terumasa, Fukuhara Takasuke, Kawaoka Yoshihiro, Sato Kei

Abstract excerpt

During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, at the time of writing, four variants of concern are considered to be potentially hazardous to human society1. The recently emerged B.1.617.2/Delta variant of concern is closely associated with the COVID-19 surge that...

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PMID: 34823256
DOI: 10.1038/s41586-021-04266-9
PMCID: PMC8828475

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