Article
Fundamental immune-oncogenicity trade-offs define driver mutation fitness.
Nature - 1 Jun 2022
Hoyos David, Zappasodi Roberta, Schulze Isabell, Sethna Zachary, de Andrade Kelvin César, Bajorin Dean F, Bandlamudi Chaitanya, Callahan Margaret K, Funt Samuel A, Hadrup Sine R, Holm Jeppe S, Rosenberg Jonathan E, Shah Sohrab P, Vázquez-García Ignacio, Weigelt Britta, Wu Michelle, Zamarin Dmitriy, Campitelli Laura F, Osborne Edward J, Klinger Mark, Robins Harlan S, Khincha Payal P, Savage Sharon A, Balachandran Vinod P, Wolchok Jedd D, Hellmann Matthew D, Merghoub Taha, Levine Arnold J, Łuksza Marta, Greenbaum Benjamin D
Abstract excerpt
Missense driver mutations in cancer are concentrated in a few hotspots1. Various mechanisms have been proposed to explain this skew, including biased mutational processes2, phenotypic differences3-6 and immunoediting of neoantigens7,8; however, to our knowledge, no existing model weighs the relative contribution of these features to tumour evolution. We propose a unified theoretical 'free fitness' framework that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.