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Article

Immunogenicity and Immune Silence in Human Cancer.

Frontiers in immunology - 1 Jan 2020

Yarmarkovich Mark, Farrel Alvin, Sison Artemio, di Marco Moreno, Raman Pichai, Parris Joshua L, Monos Dimitrios, Lee Hongzhe, Stevanovic Stefan, Maris John M

Abstract excerpt

Despite recent advances in cancer immunotherapy, the process of immunoediting early in tumorigenesis remains obscure. Here, we employ a mathematical model that utilizes the Cancer Genome Atlas (TCGA) data to elucidate the contribution of individual mutations and HLA alleles to the immunoediting process. We find that common cancer mutations including BRAF-V600E and KRAS-G12D are predicted to bind none of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32256484
DOI: 10.3389/fimmu.2020.00069
PMCID: PMC7092187

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