Article
Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals.
PLoS genetics - 1 Feb 2021
Claeys Arne, Luijts Tom, Marchal Kathleen, Van den Eynden Jimmy
Abstract excerpt
Cancer is driven by somatic mutations that result in a cellular fitness advantage. This selective advantage is expected to be counterbalanced by the immune system when these driver mutations simultaneously lead to the generation of neoantigens, novel peptides that are presented at the cancer cell membrane via HLA molecules from the MHC complex. The presentability of these peptides is determined by a patient's MHC...
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