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Article

Genome-Wide Mapping of Plasma IgG N-Glycan Quantitative Trait Loci Identifies a Potentially Causal Association between IgG N-Glycans and Rheumatoid Arthritis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2022

Liu Di, Dong Jing, Zhang Jie, Xu Xizhu, Tian Qiuyue, Meng Xiaoni, Wu Lijuan, Zheng Deqiang, Chu Xi, Wang Wei, Meng Qun, Wang Youxin

Abstract excerpt

Observational studies highlight associations of IgG N-glycosylation with rheumatoid arthritis (RA); however, the causality between these conditions remains to be determined. Standard and multivariable two-sample Mendelian randomization (MR) analyses integrating a summary genome-wide association study for RA and IgG N-glycan quantitative trait loci (IgG N-glycan-QTL) data were performed to explore the potentially...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35545292
DOI: 10.4049/jimmunol.2100080

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