Article
Multivariate genome-wide analysis of immunoglobulin G N-glycosylation identifies new loci pleiotropic with immune function.
Human molecular genetics - 17 Jun 2021
Shadrina Alexandra S, Zlobin Alexander S, Zaytseva Olga O, Klarić Lucija, Sharapov Sodbo Z, D Pakhomov Eugene, Perola Marcus, Esko Tonu, Hayward Caroline, Wilson James F, Lauc Gordan, Aulchenko Yurii S, Tsepilov Yakov A
Abstract excerpt
The N-glycosylation of immunoglobulin G (IgG) affects its structure and function. It has been demonstrated that IgG N-glycosylation patterns are inherited as complex quantitative traits. Genome-wide association studies identified loci harboring genes encoding enzymes directly involved in protein glycosylation as well as loci likely to be involved in regulation of glycosylation biochemical pathways. Many of these...
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