Article
IgG glycosylation changes and MBL2 polymorphisms: associations with markers of systemic inflammation and joint destruction in rheumatoid arthritis.
The Journal of rheumatology - 1 Mar 2012
Troelsen Lone N, Jacobsen Søren, Abrahams Jodie L, Royle Louise, Rudd Pauline M, Narvestad Eva, Heegaard Niels H, Garred Peter
Abstract excerpt
OBJECTIVE: To examine whether IgG glycosylation changes and MBL2 genotypes are associated with systemic inflammation and joint destruction in rheumatoid arthritis (RA). METHODS: IgG N-glycan content was determined from serum in 118 patients with RA by high-throughput glycan analysis using normal-phase high-pressure liquid chromatography. MBL2 extended genotypes (YA/YA, YA/XA, XA/XA, YA/YO, XA/YO, YO/YO) were...
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