Article
Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency.
International journal of cancer - 15 May 2014
Dawson Heather, Galván José A, Helbling Melina, Muller Dominique-Elisabeth, Karamitopoulou Eva, Koelzer Viktor H, Economou Mary, Hammer Caroline, Lugli Alessandro, Zlobec Inti
Abstract excerpt
Colorectal cancer is a heterogeneous disease at the histomorphological, clinical and molecular level. Approximately 20% of cases may progress through the "serrated" pathway characterized by BRAF mutation and high-level CpG Island Methylator Phenotype (CIMP). A large subgroup are additionally microsatellite instable (MSI) and demonstrate significant loss of tumor suppressor Cdx2. The aim of this study is to...
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