Article

Global Proteomic Analysis of Colorectal Cancers Stratified by Microsatellite Instability Subtype Reveals Protein Differences

2026-01-29

Abstract excerpt

Lynch syndrome, historically known as hereditary nonpolyposis colorectal cancer, is caused by germline mutations in the DNA mismatch repair (MMR) genes, MLH1, MSH2 (EPCAM), MSH6 , and PMS2 . While the genetic changes associated with Lynch Syndrome have previously been characterized, there have not been studies of the associated proteomic alterations, in part because of the limited availability of primary samples...

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Literature Corpus work: cfdb1cad-2ec4-5db0-8418-85d438b84fae
DOI: 10.64898/2026.01.28.702312

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