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Article

Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway.

International journal of cancer - 1 Apr 2016

Sakai Eiji, Fukuyo Masaki, Ohata Ken, Matsusaka Keisuke, Doi Noriteru, Mano Yasunobu, Takane Kiyoko, Abe Hiroyuki, Yagi Koichi, Matsuhashi Nobuyuki, Fukushima Junichi, Fukayama Masashi, Akagi Kiwamu, Aburatani Hiroyuki, Nakajima Atsushi, Kaneda Atsushi

Abstract excerpt

To clarify molecular alterations in serrated pathway of colorectal cancer (CRC), we performed epigenetic and genetic analyses in sessile serrated adenoma/polyps (SSA/P), traditional serrated adenomas (TSAs) and high-methylation CRC. The methylation levels of six Group-1 and 14 Group-2 markers, established in our previous studies, were analyzed quantitatively using pyrosequencing. Subsequently, we performed...

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Source

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Identifiers

PMID: 26510091
DOI: 10.1002/ijc.29903
PMCID: PMC4737347

Genes

MLH1
BRAF
MSH3
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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