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Article

AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology

7 May 2022

Abstract excerpt

Abstract Background Changes in the expression and activity of the AKT oncogene play an important role in psychiatric disease. We present translational data assessing the role of AKT in psychiatric symptoms. Methods (1) We assessed the protein activity of an AKT3 mutant harboring a PH domain mutation (Q60H) detected in a patient with schizophrenia, the corresponding AKT1 mutant (Q61H), and wild-type AKT1 and AKT3...

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PMID: 35525984
DOI: 10.1186/s13578-022-00793-8

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