Article
AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families.
Biological psychiatry - 1 Mar 2008
Thiselton Dawn L, Vladimirov Vladimir I, Kuo Po-Hsiu, McClay Joseph, Wormley Brandon, Fanous Ayman, O'Neill Francis A, Walsh Dermot, Van den Oord Edwin J C G, Kendler Kenneth S, Riley Brien P
Abstract excerpt
BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction pathway is critical to cell growth and survival. In vitro functional studies indicate that the candidate schizophrenia susceptibility gene DTNBP1 influences AKT signaling to promote neuronal viability. The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of...
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