Article
Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients.
PloS one - 1 Jan 2012
van Beveren Nico J M, Buitendijk Gabrielle H S, Swagemakers Sigrid, Krab Lianne C, Röder Christian, de Haan Lieuwe, van der Spek Peter, Elgersma Ype
Abstract excerpt
BACKGROUND: Recent studies have suggested that deregulated AKT1 signaling is associated with schizophrenia. We hypothesized that if this is indeed the case, we should observe both decreased AKT1 expression as well as deregulation of AKT1 regulated pathways in Peripheral Blood Mononuclear Cells (PBMCs) of schizophrenia patients. OBJECTIVES: To examine PBMC expression levels of AKT1 in schizophrenia patients versus...
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