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Phosphoinositide-3-kinase regulatory subunit 1 gene polymorphisms are associated with schizophrenia and bipolar disorder in the Han Chinese population.

Metabolic brain disease - 1 Jun 2020

Huang Jiao, Chen Zhaoxia, Zhu Lulu, Wu Xulong, Guo Xiaojing, Yang Jialei, Long Jianxiong, Su Li

Abstract excerpt

Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric disorders that share many genetic risk factors. This study aimed to investigate the association of phosphoinositide-3-kinase regulatory subunit1 (PIK3R1) gene rs3756668 and rs3730089 polymorphisms with SCZ and BD risks and determine the expression levels of PIK3R1. A total of 548 SCZ cases, 512 BD cases, and 598 healthy controls were included in...

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PMID: 32193760
DOI: 10.1007/s11011-020-00552-z

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