Article
Plasma TGF-β₁ in pediatric cystic fibrosis: potential biomarker of lung disease and response to therapy.
Pediatric pulmonology - 1 Jul 2011
Harris William T, Muhlebach Marianne S, Oster Robert A, Knowles Michael R, Clancy J P, Noah Terry L
Abstract excerpt
INTRODUCTION: Transforming growth factor beta-1 (TGF-β₁) is an important genetic modifier of lung disease severity in cystic fibrosis (CF), yet the mechanism behind this disease association remains unknown. Initial steps in the investigation of the relationship between TGF-β₁ and CF lung disease include determining the most appropriate available biospecimen for TGF-β₁ protein measurement. HYPOTHESIS: In...
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