The CYP2B6 G516T polymorphism influences CD4+ T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon.

doi:10.1016/j.ijid.2016.12.002

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The CYP2B6 G516T polymorphism influences CD4+ T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Feb 2017

Queiroz Maria Alice Freitas, Laurentino Rogério Valois, da Silva Graça Amoras Ednelza, Araújo Mauro Sérgio Moura de, Gomes Samara Tatielle Monteiro, Lima Sandra Souza, Vallinoto Antonio Carlos Rosário, de Oliveira Guimarães Ishak Marluísa, Ishak Ricardo, Machado Luiz Fernando Almeida

Abstract excerpt

OBJECTIVES: Cytochrome P450 (CYP) enzyme polymorphisms seem to significantly influence the variability of the responses to certain antiretroviral drugs and their toxicity levels. The objective of this study was to evaluate the influence of the CYP2B6 G516T polymorphism on hepatic, renal, immunological, and viral marker changes in HIV-1-positive patients receiving treatment in an ethnically diverse region of the...

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PMID: 27940179
DOI: 10.1016/j.ijid.2016.12.002

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