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Large variability in plasma efavirenz concentration in Papua New Guinea HIV/AIDS patients associated with high frequency of CYP2B6 516T allele.

Clinical and translational science - 1 Nov 2021

Bordin Andriguetti Natália, Van Schalkwyk Helena Katherina, Barratt Daniel Thomas, Tucci Joseph, Pumuye Paul, Somogyi Andrew Alexander

Abstract excerpt

Papua New Guinea (PNG) has a high HIV/AIDS prevalence and very high frequency of the CYP2B6 c.516G>T (rs3745274) variant. We have conducted the first investigation of the impact of c.516G>T and patient demographics on plasma efavirenz (EFV) and 8-hydroxyefavirenz (8OH-EFV) concentrations, metabolic ratio (8OH-EFV/EFV) (MR), and their association with adverse effects, in PNG patients with HIV/AIDS. For 156 PNG...

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Alkynes
Benzoxazines
Cyclopropanes
Cytochrome P-450 CYP2B6

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Papua New Guinea

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PMID: 34415664
DOI: 10.1111/cts.13120
PMCID: PMC8604234

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