Article
Brief Report: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-Treated HIV-Infected Patients in Botswana.
Journal of acquired immune deficiency syndromes (1999) - 1 Aug 2017
Vujkovic Marijana, Bellamy Scarlett L, Zuppa Athena F, Gastonguay Marc, Moorthy Ganesh S, Ratshaa Bakgaki R, Han Xiaoyan, Steenhoff Andrew P, Mosepele Mosepele, Strom Brian L, Aplenc Richard, Bisson Gregory P, Gross Robert
Abstract excerpt
BACKGROUND: CYP2B6 polymorphisms that affect efavirenz (EFV) concentrations are common, but the effect of this polymorphism on HIV virologic failure in clinical practice settings has not fully been elucidated. Our objective was to investigate the relationship between the CYP2B6 516G>T genotype and late virologic failure in patients treated with EFV in Gaborone, Botswana. SETTING: We performed a case-control study...
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