Article
CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe.
BMC pharmacology & toxicology - 27 Mar 2015
Dhoro Milcah, Zvada Simbarashe, Ngara Bernard, Nhachi Charles, Kadzirange Gerald, Chonzi Prosper, Masimirembwa Collen
Abstract excerpt
BACKGROUND: Efavirenz (EFV) therapeutic response and toxicity are associated with high inter-individual variability attributed to variation in its pharmacokinetics. Plasma concentrations below 1 μg/ml may result in virologic failure and above 4 μg/ml, may result in central nervous system adverse effects. This study used population pharmacokinetics modeling to explore the influence of demographic and...
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