Article

Transcriptome and microRNAome profiling of human skeletal muscle in pancreatic cancer cachexia

2025-09-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Over 80% of patients with pancreatic cancer experience cachexia, characterized by severe muscle and fat loss. While all the mechanistic understanding comes from preclinical models, the translatable nature of these findings to humans remains a critical gap due to the limited knowledge of human cachexia biology. <h4>Methods</h4> We generated matched gene and microRNA...

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Literature Corpus work: 9c51d02d-8564-5c53-b228-4dfbde5c6284
DOI: 10.1101/2025.09.02.25334959

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