Article

Proteomic Analysis of Bioreactor Cultures of an Antibody Expressing CHOGS Cell Line that Promotes High Productivity

2013-01-01

Abstract excerpt

Antibody manufacturing cell line development at Janssen Research & Development involves transfection of therapeutic antibody genes into a CHO-GS host cell line and isolating primary transfectomas that upon cloning yield high expressing cell lines secreting the desired antibody products. Subsequently, these cell lines are cultivated in stirred tank bioreactors for the large-scale generation of the products. In an a...

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Literature Corpus work: b276aae3-ce4b-5e1b-ba48-ad6b8493b2fb
DOI: 10.4172/jpb.1000268

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