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Integrative Sequencing and Proteogenomic Approaches to Intratumoral Heterogeneity in Cholangiocarcinoma: Implications for Precision Diagnosis and Therapy.

Medical sciences (Basel, Switzerland) - 7 Jan 2026

Sitthirak Sirinya, Wangwiwatsin Arporn, Jusakul Apinya, Namwat Nisana, Klanrit Poramate, Roytrakul Sittiruk, Dokduang Hasaya, Duangchan Thitinat, Rattanapan Yanisa, Titapun Attapol, Jareanrat Apiwat, Thanasukarn Vasin, Khuntikeo Natcha, Tean Teh Bin, Boulter Luke, Murakami Yoshinori, Loilome Watcharin

Abstract excerpt

Cholangiocarcinoma (CCA) is a highly aggressive cancer of the biliary tract, distinguished by significant intratumoral heterogeneity (ITH), which contributes to therapy resistance and unfavorable clinical outcomes. Traditional genome profiling has revealed recurring driver changes in CCA; yet, genomic data alone fails to elucidate functional pathway activation, adaptive signaling, and the diverse treatment...

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PMID: 41562920
DOI: 10.3390/medsci14010030
PMCID: PMC12821467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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