Article
Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets.
Nature communications - 29 Oct 2022
Fujita Masashi, Chen Mei-Ju May, Siwak Doris Rieko, Sasagawa Shota, Oosawa-Tatsuguchi Ayako, Arihiro Koji, Ono Atsushi, Miura Ryoichi, Maejima Kazuhiro, Aikata Hiroshi, Ueno Masaki, Hayami Shinya, Yamaue Hiroki, Chayama Kazuaki, Lee Ju-Seog, Lu Yiling, Mills Gordon B, Liang Han, Nishizuka Satoshi S, Nakagawa Hidewaki
Abstract excerpt
Primary liver cancer is a heterogeneous disease in terms of its etiology, histology, and therapeutic response. Concurrent proteomic and genomic characterization of a large set of clinical liver cancer samples can help elucidate the molecular basis of heterogeneity and thus serve as a valuable resource for personalized liver cancer treatment. In this study, we perform proteomic profiling of ~300 proteins on 259...
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