Article
Resistance to SMO Inhibitors in Advanced Basal Cell Carcinoma: A Case Highlighting the Role of Molecular Tumor Profiling.
International journal of molecular sciences - 21 Dec 2025
Papaccio Federica, Marrapodi Ramona, Eibenschutz Laura, D'Arino Andrea, Caputo Silvia, Marini Alberto, Scano Simona, Presaghi Arianna, Cota Carlo, Melucci Elisa, Scalera Stefano, Migliano Emilia, Maugeri-Saccà Marcello, Frascione Pasquale, Bellei Barbara
Abstract excerpt
Basal cell carcinoma (BCC) is the most common skin cancer, predominantly affecting sun-exposed areas. It typically grows slowly and rarely metastasizes, though untreated cases can cause significant tissue destruction and morbidity. Its pathogenesis primarily involves dysregulation of the Hedgehog (HH) signaling pathway, mainly through mutations in PTCH1 or SMO genes, leading to chronic activation of downstream...
Topics
- Humans
- Basal Cell Carcinoma
- Female
- Skin Neoplasms
- Smoothened Receptor
- Drug Resistance, Neoplasm
- Pyridines
- Biphenyl Compounds
- Mutation