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Article

Associations of keratinocyte cancers with snp variants in the sonic hedgehog pathway.

BMC cancer - 3 May 2022

Rodriguez-Acevedo Astrid J, Antonsson Annika, Liyanage Upekha E, Hughes Maria Celia, Gordon Scott, van der Pols Jolieke, Green Adele C

Abstract excerpt

BACKGROUND: Sonic Hedgehog (SHH) pathway dysregulation is implicated in basal cell carcinoma (BCC) development. To evaluate the possible wider role of SHH gene variants in skin carcinogenesis, we assessed associations of genes in the SHH pathway with lifetime development of any keratinocyte cancer (KC), and with developing either BCCs or squamous cell carcinomas (SCCs) exclusively, in a 25-year prospective,...

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Source

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Identifiers

PMID: 35505292
DOI: 10.1186/s12885-022-09565-6
PMCID: PMC9063108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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