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Article

A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer.

Cancer epidemiology - 1 Oct 2012

Jorgensen Timothy J, Ruczinski Ingo, Yao Shugart Yin, Wheless Lee, Berthier Schaad Yvette, Kessing Bailey, Hoffman-Bolton Judith, Helzlsouer Kathy J, Kao W H Linda, Francis Lesley, Alani Rhoda M, Strickland Paul T, Smith Michael W, Alberg Anthony J

Abstract excerpt

INTRODUCTION: A personal history of basal cell carcinoma (BCC) is associated with increased risk of other malignancies, but the reason is unknown. The hedgehog pathway is critical to the etiology of BCC, and is also believed to contribute to susceptibility to other cancers. This study tested the hypothesis that hedgehog pathway and pathway-related gene variants contribute to the increased risk of subsequent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22677152
DOI: 10.1016/j.canep.2012.05.001
PMCID: PMC3438291

Genes

FAS
VDR
GLI1
IHH
PTCH2
SHH
SMO
SUFU

Provenance

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