Article
Relation between sonic hedgehog pathway gene polymorphisms and basal cell carcinoma development in the Polish population.
Archives of dermatological research - 1 Jan 2016
Lesiak Aleksandra, Sobolewska-Sztychny Dorota, Majak Paweł, Sobjanek Michał, Wodz Karolina, Sygut Karolina Przybyłowska-, Majsterek Ireneusz, Wozniacka Anna, Narbutt Joanna
Abstract excerpt
In recent decades, increases have been observed in the incidence of nonmelanoma skin cancers, including basal cell carcinoma (BCC) and squamous cell carcinoma. BCC is the most common neoplasm in Caucasian populations. Sonic hedgehog (Shh) pathway impairment plays a key role in BCC pathogenesis, and there is evidence that Shh pathway genetic variations may predispose to BCC development. We genotyped 22...
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