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Article

SirT1 brings stemness closer to cancer and aging

9 Feb 2011

Abstract excerpt

Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of SirT1 biology, its function as a stem cell pluripotency and differentiation regulator. We evaluate the implications of these findings in sirtuin inhibition-based cancer treatment and in the application of sirtuin...

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PMID: 21307403
DOI: 10.18632/aging.100272

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